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Inventi Impact: Cardiology & Haematology

Articles

  • Inventi:hch/33026/20
    Matrix Metalloproteinase-2 Isoforms Differ Within the Aortic Wall of Ascending Aortic Aneurysms Associated with Bicuspid Aortic Valve
    Research 2021 : January - March
    Ramona Schmitt, Anke Tscheuschler, Philipp Laschinski, Philipp Discher, Jana Fuchs, Fabian A Kari

    The pathogenesis of ascending thoracic aortic aneurysm (aTAA) is thought to differ between patients with bicuspid aortic valve\n(BAV) and tricuspid aortic valve (TAV), and one of the causes is different hemodynamics. Influenced by hemodynamics, the\ntissue levels of proteins associated with aTAA might differ between aTAAs with BAV and TAV and between different localities\nwithin the aortic wall. We therefore analyzed aTAA tissue levels of MMP-2 (matrix metalloproteinase-2) isoforms (Pro-MMP-2,\nactive MMP-2, and total MMP-2) and tissue levels of MMP-14, TIMP-2 (tissue inhibitor of metalloproteinase-2), MMP-9, and\nTIMP-1 in 19 patients with BAV and 23 patients with TAV via gelatin zymography and enzyme-linked immunosorbent assay\n(ELISA), respectively. TAV and BAV groupsâ?? protein levels did not differ significantly........................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Schmitt, Ramona, et al. \"Matrix Metalloproteinase-2 Isoforms Differ within the Aortic Wall of\nAscending Aortic Aneurysms Associated with Bicuspid Aortic Valve.\" Cardiology Research and Practice 2020 (2020).\nhttps://doi.org/10.1155/2020/1306425\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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